scientific presentations and publications

Selected scientific papers and presentations from Cytopia scientists

J.D. Lickliter, G.D. SMITH, M. Burge, A. Coulthard, D. Wyld, C. Roberts, G. Parker, P.A. Vasey. Phase I study of CYT997, a novel cytotoxic and vascular disrupting agent, given as a 24-hour intravenous infusion to patients with advanced solid tumours. Abstract from ASCO Meeting in Chicago June 2007. Click here to view abstract (pdf file).

A.F. WILKS, C.J. BURNS, G.D. SMITH, E.FANTINO, I.D. PHILLIPS, M. MCNALLY, D.G. BOURKE, L.N. ANDRAU, N.W. COURT, P.E. BUKCZYNSKA, M. JOFFE, A. Tefferi T. Pardanani. W. Lasho, O. Stevenson. A. Cooley. E. Roberts, T. O’Flaherty, J. Bumm, J. Deininger, M. Tyner, A. Deininger. A novel JAK2 inhibitor for the treatment of myeloproliferative disorders.  Abstract from AACR Meeting, San Diego Apr 2008. Click here to view abstract (pdf file).

M. HARTE, M. GIARRUSSO, C.J. BURNS, J. PALMER, L. ANDRAU, P. RAZZINO, S. SU, E. FANTINO, M. JOFFE, S. SAN WAN, S. LEGGE, H.R. TREUTLEIN, A.F WILKS, Bernadette Scott, Paul Hertzog. Novel Inhibitors of FMS Kinase. Abstract from 6th CHI Protein Kinase Targets Meeting 23-25th June, 2008, Boston, USA. Click here to view abstract (pdf file).

M. Walter, I.S. Lucet, O. Patel, S.E. Broughton, R. Bamert, N.K. Williams, E. FANTINO, A.F. WILKS, J. Rossjohn. The 2.7Å crystal structure of the autoinhibited human c-Fms kinase domain. J Mol Biol. 2007, 367, 839.

I.S. Lucet, E. FANTINO, M. STYLES, R. Bamert, O. Patel, S.E. Broughton, M. Walter, C.J. BURNS, H.R. TREUTLEIN, A.F. WILKS, J. Rossjohn. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood. 2006, 107, 176-83..

K. M. Irvine, C.J. BURNS, A.F. WILKS, S. SU, D.A. Hume, M.J. Sweet. A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. FASEB J. 2006, 20, 1921.

S. LEGGE, A. Budi., H.R. TREUTLEIN , I. Yarovsky. Protein Flexibility: Multiple Molecular Dynamics Simulations of Insulin Chain B. Biophys. Chem. 2006, 119, 146.

Selective targeting of tumour vasculature by the novel synthetic molecule CYT997 and its efficacy in preclinical cancer models; poster presentation at AACR annual meeting 2005, Annaheim, California. Click here to view abstract and poster (pdf file).

ChemaPhore: Tool for Pragmatic Computer-Aided Structure-Based Drug Design; poster presentation at Drug Discovery Technology Meeting in Boston, August 2005. Click here to view poster (pdf file).

JAK/STAT signaling pathway negatively regulates angiotensin II AT1 receptor induced cardiac hypertrophy in rat cardiomyocytes, Poster presentation at 12th International Conference on Second Messengers and phosphoproteins (SMP 2004) August 3-7, 2004, Montreal, Canada. Click here to view poster (pdf file).